CULTURELLE® is an all-natural dietary supplement containing the probiotic, Lactobacillus rhamnosus GG (LGG®). Developed in 1985 and patented in the US in 1987 by Dr. Sherwood Gorbach and Dr. Barry Goldin, of Tufts University, LGG, the subject of 250 clinical reports and studies, is the most widely researched strain of probiotic in the world.**