St. John’s Wort

Also indexed as: Hypericum, Klamath Weed

Drug Interactions

Certain medicines interact with St. John’s wort: Some interactions may increase the need for St. John’s wort (Beneficial), other interactions may be negative (Avoid) and indicate St. John’s wort should not be taken without first speaking with your physician or pharmacist, others may require further explanation (Check). Refer to the individual drug article for specific details about an interaction.

Note: the following list only includes the generic or class name of a medicine—to find a specific brand name, use the Safetychecker index.

Benzodiazepines Avoid

Chemotherapy Avoid

Cyclosporine Avoid

Digoxin Avoid

Fexofenadine Check

Fluoxetine Avoid

Fluvoxamine Avoid

Indinavir Avoid

Nefazodone Avoid

Oral Contraceptives Avoid

Paroxetine Avoid

Phenelzine Avoid

Sertraline Avoid

Theophylline/Aminophylline Avoid

Trazodone Avoid

Tricyclic Antidepressants Avoid

Venlafaxine Avoid

Warfarin Avoid