Gamma Oryzanol

What does it do?

Gamma oryzanol is a naturally occurring mixture of plant chemicals called sterols and ferulic acid esters.

Some evidence suggests that gamma oryzanol increases testosterone levels, stimulates the release of endorphins (pain-relieving substances made in the body), and promotes the growth of lean muscle tissue.1 Supplementation with gamma oryzanol for nine weeks did not influence exercise performance in male weight lifters.2

Where is it found?

Gamma oryzanol is a natural component of rice bran, corn, and barley oils. Gamma oryzanol is also available as a supplement.

Gamma oryzanol has been used in connection with the following condition (refer to the individual health concern for complete information):

Rating Health Concerns
2Stars

Gastritis
1Star

Athletic performance
3Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Who is likely to be deficient?

Since gamma oryzanol is not an essential nutrient, it is not associated with a deficiency state.

How much is usually taken?

Much of the human research with gamma oryzanol used 300 mg per day. Healthy people do not appear to need this supplement.

Are there any side effects or interactions?

Some research suggests that gamma oryzanol taken in moderately high amounts (up to 600 mg per day) for several months can cause dry mouth, sleepiness, hot flushes, irritability, and light headedness in some individuals.3

At the time of writing, there were no well-known drug interactions with gamma oryzanol.

References

1. Rosenbloom C, Millard-Stafford M, Lathrop J. Contemporary ergogenic aids used by strength/power athletes. J Am Diet Assoc 1992;92:1264-5.

2. Fry AC, Bonner E, Lewis DL, et al. The effects of gamma-oryzanol supplementation during resistance exercise training. Int J Sport Nutr 1997;7:318-29.

3. 34. Takemoto T, Miyoshi H, Nagashima H. Clinical trial of Hi-Z fine granules (gamma-oryzanol) on gastrointestinal symptoms at 375 hospitals (Japan). Shinyaku To Rinsho 1977;26 [in Japanese].