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Vitamin D3 250 mcg (10,000 IU)
Vitamin D3 250 mcg (10,000 IU)
Vitamin D3 250 mcg (10,000 IU)
Vitamin D3 250 mcg (10,000 IU)
Vitamin D3 250 mcg (10,000 IU)

Vitamin D3 250 mcg (10,000 IU)

Item #035872
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immune icon

Not sure where to start
with immune health?

Then this is a great place to begin.
This content is intended as general information. We encourage you to explore the full Puritan’s Pride’s® Immune Health offerings for product-specific benefits.

Vitamin D for Immune Health

Vitamin D is a fat-soluble vitamin that can be obtained through the diet or synthesized in the skin upon exposure to sunlight. Vitamin D3, the form of vitamin D formed in the skin, is a potent and active form of the vitamin. Vitamin D2 is a vitamin D analog formed in plants, mushrooms and yeasts during photosynthesis. While vitamin D2 is sometimes used in food fortification, Puritan’s Pride supplements provide the active form.

Vitamin D plays a regulatory role in the growth, differentiation, and proliferation of different types of white blood cells.8** It is important to regulate these processes to maintain immune balance. Think of a thermostat set to 70 degrees.

When the temperature falls below 70 degrees the heat comes on but once the temperature is reached, the heat needs to turn off or else the temperature will continue to rise indefinitely. The same delicate balance is needed for our immune systems to maintain optimal health.

The T and B cells of the adaptive immune system are both regulated by vitamin D.** Many cells of the innate immune response also require vitamin D such as monocytes which need it to mature properly.** Adequate concentrations of vitamin D are also necessary for the synthesis of important proteins with immune-fighting properties.8**

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Why Supplement with Vitamin D?

As many as 96% of Americas do not get enough vitamin D from food alone.9

Did you know, Vitamin D is considered a nutrient of public health concern? This is because many Americas are not getting enough vitamin D in their diets and low intakes are associated with health concerns.

This is partly because natural food sources of vitamin D are limited and not always appealing. They include cod liver oil, liver and some types of fatty fish such as mackerel, salmon, and sardines. In the US, milk but not all dairy products, is fortified with vitamin D. It is important to check the label on products like cheese and yogurt to see if they were made with fortified milk.

The RDA for vitamin D is currently 15-20 mcg/day depending on age.

However, this level was established based on the amount of vitamin D needed to maintain bone health.** Many health experts argue that higher intakes of vitamin D are necessary for overall optimal health. A daily intake of 50 mcg (2,000 IU) is frequently recommended for most healthy adults.12


Unlike most vitamins that can only be obtained from the diet, our bodies produce vitamin D when the skin is exposed to sunlight. When evaluating if sun exposure is enough to meet your daily vitamin D needs, consider the following factors.

AGE

As we age, the skin produces vitamin D less efficiently. Vitamin D absorption may also decrease with age, making vitamin D supplementation especially beneficial for older individuals.

SUNSCREEN

When used as directed, a sunscreen graded SPF-10 will block 90% of UVB radiation reaching the skin.10 UVB radiation is needed to stimulate production of vitamin D.

LOCATION

Residents of northern climates may have inadequate exposure to sunlight in order to produce sufficient vitamin D, especially during the winter months.

CLOTHING

Wearing protective clothing such as hats and long sleeves inhibits the body’s natural production
of vitamin D.

SUN INTENSITY

The stimulation of vitamin D production in skin can depend on the intensity of the sun’s UVB rays. When you are shorter than your shadow, UVB radiation is often not strong enough to produce vitamin D.11 Air pollution and the presence of clouds can also have a major impact on the intensity of UVB radiation that reaches the ground.

  • References
  • 8. Gropper SS, Smith JL, Groff, JL. Fifth edition. Belmont, CA: Wadsworth/Cengage Learning; 2009.
  • 9. Dickinson A, MacKay D. Nutr J. 2014;13:14.
  • 10. Council on Environmental Health, Section on Dermatology, Balk SJ. Pediatrics. 2011 Mar;127(3):588-97.
  • 11. Gorham E. Vitamin D wiki website. October 2015. Accessed July 2, 2020. https://vitamindwiki.com/The+Shadow+Rule+%E2%80%93+you+make+Vitamin+D+when+you+are+taller+than+your+shadow+%E2%80%93+1992
  • 12. Calder PC, et al. Nutrients. 2020;12(4):1181.

What is the Immune System?

Every day, your body is bombarded by foreign substances from the outside world. Credit card pin pads, bathroom faucets, cell phones, literally everything you touch is covered in tiny microorganisms. Not all microorganisms are bad, in fact there are trillions of bacteria found in and on the human body which cause no harm, or in some cases are even beneficial to human health.

However, there are also less favorable microorganisms found in the environment. The main function of your immune system is to protect you from external threats and keep you healthy.

Think of your immune system as your body’s security team, trained to recognize and remove any threats while protecting your body’s peaceful residents.

The first line of defense is to restrict the entry of unwanted foreign materials. The skin creates an excellent physical barrier but unwanted guests may still be inhaled or ingested. The acidity of stomach acid, mucosal membranes, and the presence of antibodies in saliva and tears all further help to prevent the entry of these substances into the body.

Four Main Functions
of the Immune System

icon exclusion
Exclusion Barrier

Physical barriers keep pathogens from entering the body – e.g. skin, mucosa layer of GI tract, antibodies in saliva, pH of stomach

icon recognition
Recognition

If substances get through the exclusion barrier, they need to be recognized as non-self

icon elimination
Elimination

Elimination only of unwanted threats, not self or friendly bacteria

icon memory
Memory

Immune memories allow for fast recognition and elimination of repeat offenders


1

Your First Line of Defense: Innate Immune System

If a non-beneficial microorganism is able to pass through your body’s first line of defense, it must be recognized by your immune system. Recognition is an important feature of your patrolling security team. Without it, your immune system would attack non-threatening foreign substances and even your own cells. Undesirable substances are recognized by white blood cells that send messages akin to sounding an alarm, drawing more white blood cells to the area. There are many different types of white blood cells, also called leukocytes, that all work together to orchestrate the appropriate immune response. The elements of the immune system discussed thus far are all considered part of the innate response.

Characterized as being fast and non-specific, the innate immune system responds within minutes or hours.1 Once the innate immune system has identified a threat, it seeks to eliminate it. The various white blood cells of the innate immune system each fight these threats in their own unique ways. Some will trigger an inflammatory response while others will deal with it directly by engulfing it or releasing toxic chemicals. Since the innate immune response is non-specific, the response is generally the same regardless of whether the same pathogen is encountered numerous times.


2

Your Second Line of Defense: Adaptive Immune Response

If a non-beneficial microorganism is able to pass through your body’s first line of defense, it must be recognized by your immune system. Recognition is an important feature of your patrolling security team. Without it, your immune system would attack non-threatening foreign substances and even your own cells. Undesirable substances are recognized by white blood cells that send messages akin to sounding an alarm, drawing more white blood cells to the area. There are many different types of white blood cells, also called leukocytes, that all work together to orchestrate the appropriate immune response. The elements of the immune system discussed thus far are all considered part of the innate response.

Characterized as being fast and non-specific, the innate immune system responds within minutes or hours.1 Once the innate immune system has identified a threat, it seeks to eliminate it. The various white blood cells of the innate immune system each fight these threats in their own unique ways. Some will trigger an inflammatory response while others will deal with it directly by engulfing it or releasing toxic chemicals. Since the innate immune response is non-specific, the response is generally the same regardless of whether the same pathogen is encountered numerous times.

Factors that
Affect Immune Health

Your immune system is always patrolling your body to keep you at your best, but you need to keep your immune system healthy too. Every day you need to provide your immune system with the energy and nutrients it needs to function optimally.

age block

AGE: The immune response starts to weaken around age 60 and continues to weaken with age.2

sleep block

SLEEP: Important immune proteins called cytokines are released while we sleep. Sleep deprivation leads to decreased immune function as well as increased recovery times.3

stress block

STRESS: Both physical and emotional stress can negatively impact the immune system. The stress hormone cortisol has been shown to decrease white blood cell numbers.7

smoking block

SMOKING:: Smoking causes dysfunction of white blood cells involved in both innate and adaptive immunity.5 It is estimated that 1.1 billion people in the world are smokers.6

sleep block

PHYSCIAL ACTIVITY: Regular moderate-intensity exercise achieved on a near-daily basis is associated with better immune health with age. More than 80% of U.S. adults are not meeting guidelines for both aerobic and muscle-strengthening activities.4

stress block

NUTRITION: The immune system needs proper nutrients to function optimally. There are a number of vitamins, minerals and other nutrients that are widely recognized for their role in supporting immune health.**

Immune
Myths & FAQs
Myth: All immune support supplements work the same way.

Because the immune system is such a complex system, there is not a one-size-fits-all approach to supporting immune health. The various different types of white blood cells, immune proteins, and tissues and organs all have different nutrient requirements. Taking a single nutrient for immune health may assist in supporting one of these aspects of immune health, but if you are lacking other nutrients in your diet, then you may be falling short in getting total immune support.**

Myth: The immune system is stronger in the summer.

The immune system works year-round to keep you healthy no matter what the season. Depending on location and lifestyle factors, vitamin D status may be higher in the summer to better support certain aspects of immune health.** Winter weather conditions such as dry air may also affect immune health. It is still important to support your immune health every day throughout the year for optimal functioning.

FAQ: How can you boost your immune system?

The immune system should not be “boosted” beyond normal, optimal functioning. In fact, many autoimmune diseases are characterized by an overactive immune system that starts attacking its own cells. There are however lifestyle changes that you can make to help support normal functioning of the immune system. These include getting adequate sleep, engaging in regular physical activity, managing stress, eating a balanced diet and getting adequate amounts of immune supporting nutrients.

FAQ: Where is the immune system?

The immune system is a complex network of organs, cells, tissues and proteins found throughout the body. It includes the thymus, spleen, bone marrow, skin, tonsils and Peyer’s patches in the intestines. The lymph system allows white blood cells of the immune system to patrol the entire body looking for foreign invaders.

References:

  • 1. Gombart AF, Pierre A, Maggini S. Nutrients. 2020;12(1):236.
  • 2. Pawelec G, Larbi A, Derhovanessian E. J Comp Pathol. 2010;142 Suppl 1:S39-S44.
  • 3. Krueger JM, Majde JA, Rector DM. Cytokines in Immune Function and Sleep Regulation.; 2011. doi:10.1016/B978-0-444-52006-7.00015-0
  • 4. President’s Council on Sports, Fitness & Nutrition. U.S. Department of Health and Human Services Website. Updated January 26, 2017. Accessed July 2, 2020. https://www.hhs.gov/fitness/resource-center/facts-and-statistics/index.html
  • 5. Qiu F, Liang CL, Liu H, et al. Oncotarget. 2017;8(1):268-284.
  • 6. Tobacco. https://www.who.int/news-room/fact-sheets/detail/tobacco. Accessed March 24, 2020.
  • 7. McGregor BA, Murphy KM, Albano DL, Ceballos RM. Stress. 2016;19(2):185-191.

Why Choose Puritan’s Pride?

Getting the most out of life every day is what inspires us to deliver over 3,000 outstanding products that help you achieve your health and wellness goals.

We take pride in manufacturing the vitamins, minerals and herbal supplements that complement your healthy lifestyle, plus we offer essential oils, nutritious foods and more.

So get out there and embrace life… because the journey is your reward.

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Customer Reviews
Rated 5 out of 5 by from Awesome! I bought this for me and my family a month ago and we are so happy
Date published: 2020-09-17
Rated 5 out of 5 by from Good Not sure if things have been helped or not. I was told to take it
Date published: 2020-08-28
Rated 5 out of 5 by from D3@10,000 - Absolute Best Bargain Anywhere Around! The Puritan's Pride Vitamin D3 @ 10,000 IUs/250 mcg is the absolute best bargain I've ever found on this supplement. Quality is always very good; shipping is reasonably fast; and the opportunity for various additional discounts has made me a "repeat buyer" on so many supplements!
Date published: 2020-08-01
Rated 5 out of 5 by from Hard to find this size in stores. Fantastic quality and great price. Hard to find this size in stores.
Date published: 2020-07-30
Rated 5 out of 5 by from Best D Really good Vitamin. Its works. Thx for fast delivery to another country!
Date published: 2020-07-14
Rated 5 out of 5 by from Excellent product I used it every day and my vitamin D level has gone up.
Date published: 2020-06-29
Rated 5 out of 5 by from Exactly want I need This is a perfect size and qty for me and the price is very competitive
Date published: 2020-06-22
Rated 5 out of 5 by from Great product and value! Great product and value! Easy to take and add to my daily routine.
Date published: 2020-06-19
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