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Echinacea Complex
Echinacea Complex
Echinacea Complex
Echinacea Complex
Echinacea Complex

Echinacea Complex

Item #000922

450 mg


100 Capsules

Earn up to 130 Puritan's Perks points. Learn More

immune icon

Not sure where to start
with immune health?

Then this is a great place to begin.
This content is intended as general information. We encourage you to explore the full Puritan’s Pride’s® Immune Health offerings for product-specific benefits.

Herbs for Immune Health

People have been practicing traditional medicine for thousands of years. There are many different systems of traditional practices that have been shaped by the environment where each first evolved such as Traditional Chinese Medicine and Ayurveda.

Throughout all of these systems the unifying philosophy is a holistic approach to wellness.8 Today, herbal supplements are the most popular and frequently used complementary health approach used by adults in the US.9 In places outside the US, traditional wellness practices are still used routinely in primary care, making up around 70% of global health care.9

The power of plants comes from phytonutrients. These compounds occur naturally in plants to help protect the plants but they can also have health-promoting properties for humans.

There are thousands of different phytonutrients with different effects on systems in the human body. Many botanicals contain phytonutrients that have immunomodulatory properties and can be used to support the immune system.**


Echinacea is a flowering herb that grows wild in the Midwestern and Eastern States. This perennial produces purple, daisy-like flowers that are also referred to as purple coneflowers. Echinacea has been used by Native Americans of the Great Plains for centuries to support immune health.** Its use also dates back to the American Eclectics in the early part of the twentieth century. Phytonutrients found within Echinacea are believe to activate the immune system.** This traditional herb has become one of the world’s leading herbs for immune support for good reason.** It can be taken any time of the year to support the body’s natural defenses.**


Elder is a flowering shrub native to most of Europe. It produces dark purple berries roughly the size of blueberries. Both the flowers and berries of the Elder plant have a long history of traditional use. Early settlers of the Americas brought their traditional practices to the New World and quickly discovered a subspecies now called American Elder.10 Native Americans had also already established a long tradition of using Elderberry for its health-promoting properties.10 Today we know elderberries contain beneficial phytonutrients called flavonoids. This traditional herb can be used to support immune health any time of year.**


Andrographis is a leafy plant native to South Asia that has an extremely bitter taste. It has long been used as an herb in Ayurvedic health practices for supporting the immune system.**

Trusted for centuries, Andrographis can now be found in one of our convenient tablets. You’ll get the benefits for immune health without the bitterness.** Our formula is standardized for the active components, including andrographolide, that deliver these benefits. Andrographis also helps support healthy nasal passages, and is sometimes referred to as "Indian Echinacea" due to it being native to India and its similar benefits as Echinacea for immune health.** Our high-quality products are manufactured in the USA from the purest sources around the world, so you can rest easy that you’re getting the best that the globe has to offer.

  • References
  • 8. Wachtel-Galor S, Benzie IFF. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 1.
  • 9.Romm A. Botanical Medicine for Women’s Health. 2nd edition. Great Britain: Elsevier, Inc; 2018.
  • 10. Charlebois D. Issues in new crops and new uses. Alexandria (VA): ASHS Press; 2007.

What is the Immune System?

Every day, your body is bombarded by foreign substances from the outside world. Credit card pin pads, bathroom faucets, cell phones, literally everything you touch is covered in tiny microorganisms. Not all microorganisms are bad, in fact there are trillions of bacteria found in and on the human body which cause no harm, or in some cases are even beneficial to human health.

However, there are also less favorable microorganisms found in the environment. The main function of your immune system is to protect you from external threats and keep you healthy.

Think of your immune system as your body’s security team, trained to recognize and remove any threats while protecting your body’s peaceful residents.

The first line of defense is to restrict the entry of unwanted foreign materials. The skin creates an excellent physical barrier but unwanted guests may still be inhaled or ingested. The acidity of stomach acid, mucosal membranes, and the presence of antibodies in saliva and tears all further help to prevent the entry of these substances into the body.

Four Main Functions
of the Immune System

icon exclusion
Exclusion Barrier

Physical barriers keep pathogens from entering the body – e.g. skin, mucosa layer of GI tract, antibodies in saliva, pH of stomach

icon recognition

If substances get through the exclusion barrier, they need to be recognized as non-self

icon elimination

Elimination only of unwanted threats, not self or friendly bacteria

icon memory

Immune memories allow for fast recognition and elimination of repeat offenders


Your First Line of Defense: Innate Immune System

If a non-beneficial microorganism is able to pass through your body’s first line of defense, it must be recognized by your immune system. Recognition is an important feature of your patrolling security team. Without it, your immune system would attack non-threatening foreign substances and even your own cells. Undesirable substances are recognized by white blood cells that send messages akin to sounding an alarm, drawing more white blood cells to the area. There are many different types of white blood cells, also called leukocytes, that all work together to orchestrate the appropriate immune response. The elements of the immune system discussed thus far are all considered part of the innate response.

Characterized as being fast and non-specific, the innate immune system responds within minutes or hours.1 Once the innate immune system has identified a threat, it seeks to eliminate it. The various white blood cells of the innate immune system each fight these threats in their own unique ways. Some will trigger an inflammatory response while others will deal with it directly by engulfing it or releasing toxic chemicals. Since the innate immune response is non-specific, the response is generally the same regardless of whether the same pathogen is encountered numerous times.


Your Second Line of Defense: Adaptive Immune Response

The body’s second line of defense is the adaptive immune response. This response takes days or even weeks to develop, but it is highly specific. Unlike the innate immune system which simply recognizes objects as good or bad, the adaptive immune system precisely identifies each foreign substance and develops a customized response. These unwanted guests are identified by the presence of antigens – which are like name tags calling out what kind of substance it is. Highly specialized white blood cells called B cells produce antibodies that fit together with the foreign substances antigens like puzzle pieces. The antibody-antigen complex signals to other immune cells that this complex needs to be destroyed.

Another type of cell of the adaptive immune system is T cells. T cells do not produce antibodies but when they recognize an antigen, some types of T cells will directly attack the foreign invader. Other types of T cells will regulate the responses of other types of immune cells. The most amazing part about the adaptive immune system is its capacity to remember the appropriate response for foreign substance through memory cells. These immune memories develop throughout your life and are readily activated when they are needed again.

Factors that
Affect Immune Health

Your immune system is always patrolling your body to keep you at your best, but you need to keep your immune system healthy too. Every day you need to provide your immune system with the energy and nutrients it needs to function optimally.

age block

AGE: The immune response starts to weaken around age 60 and continues to weaken with age.2

sleep block

SLEEP: Important immune proteins called cytokines are released while we sleep. Sleep deprivation leads to decreased immune function as well as increased recovery times.3

stress block

STRESS: Both physical and emotional stress can negatively impact the immune system. The stress hormone cortisol has been shown to decrease white blood cell numbers.7

smoking block

SMOKING: Smoking causes dysfunction of white blood cells involved in both innate and adaptive immunity.5 It is estimated that 1.1 billion people in the world are smokers.6

sleep block

PHYSICAL ACTIVITY: Regular moderate-intensity exercise achieved on a near-daily basis is associated with better immune health with age. More than 80% of U.S. adults are not meeting guidelines for both aerobic and muscle-strengthening activities.4

stress block

NUTRITION: The immune system needs proper nutrients to function optimally. There are a number of vitamins, minerals and other nutrients that are widely recognized for their role in supporting immune health.**

Myths & FAQs
Myth: All immune support supplements work the same way.

Because the immune system is such a complex system, there is not a one-size-fits-all approach to supporting immune health. The various different types of white blood cells, immune proteins, and tissues and organs all have different nutrient requirements. Taking a single nutrient for immune health may assist in supporting one of these aspects of immune health, but if you are lacking other nutrients in your diet, then you may be falling short in getting total immune support.**

Myth: The immune system is stronger in the summer.

The immune system works year-round to keep you healthy no matter what the season. Depending on location and lifestyle factors, vitamin D status may be higher in the summer to better support certain aspects of immune health.** Winter weather conditions such as dry air may also affect immune health. It is still important to support your immune health every day throughout the year for optimal functioning.

FAQ: How can you boost your immune system?

The immune system should not be “boosted” beyond normal, optimal functioning. In fact, many autoimmune diseases are characterized by an overactive immune system that starts attacking its own cells. There are however lifestyle changes that you can make to help support normal functioning of the immune system. These include getting adequate sleep, engaging in regular physical activity, managing stress, eating a balanced diet and getting adequate amounts of immune supporting nutrients.

FAQ: Where is the immune system?

The immune system is a complex network of organs, cells, tissues and proteins found throughout the body. It includes the thymus, spleen, bone marrow, skin, tonsils and Peyer’s patches in the intestines. The lymph system allows white blood cells of the immune system to patrol the entire body looking for foreign invaders.


  • 1. Gombart AF, Pierre A, Maggini S. Nutrients. 2020;12(1):236.
  • 2. Pawelec G, Larbi A, Derhovanessian E. J Comp Pathol. 2010;142 Suppl 1:S39-S44.
  • 3. Krueger JM, Majde JA, Rector DM. Cytokines in Immune Function and Sleep Regulation.; 2011. doi:10.1016/B978-0-444-52006-7.00015-0
  • 4. President’s Council on Sports, Fitness & Nutrition. U.S. Department of Health and Human Services Website. Updated January 26, 2017. Accessed July 2, 2020.
  • 5. Qiu F, Liang CL, Liu H, et al. Oncotarget. 2017;8(1):268-284.
  • 6. Tobacco. Accessed March 24, 2020.
  • 7. McGregor BA, Murphy KM, Albano DL, Ceballos RM. Stress. 2016;19(2):185-191.

Why Choose Puritan’s Pride?

Getting the most out of life every day is what inspires us to deliver over 3,000 outstanding products that help you achieve your health and wellness goals.

We take pride in manufacturing the vitamins, minerals and herbal supplements that complement your healthy lifestyle, plus we offer essential oils, nutritious foods and more.

So get out there and embrace life… because the journey is your reward.

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Trusted and Loved
by Generations of Families
for Over 45 Years

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Customer Reviews
Rated 3 out of 5 by from What Happened to the Golden Seal Root? I have purchased this product for years and was very happy with it. This year when I tried to order it was on backorder, and in maneuvering around the website, I noticed that it no longer had Goldenseal as an ingredient. Other people had commented on this. The main reason I initially purchased it is because Echinacea and Goldenseal Root are a great combination for immune system function. Puritans Pride should have notified everybody that this product no longer has 1 of it's 2 main ingredients.
Date published: 2020-05-31
Rated 3 out of 5 by from No Goldenseal Thought this product has Goldenseal as part of the complex? That's what I came to the site for.
Date published: 2020-05-25
Date published: 2020-05-15
Rated 3 out of 5 by from Not sure of hype Got this only because I couldn't get the regular Echinacea I usually purchase from Puritan Pride. I really don't see as it's any better and this bottle says take 6 per day!!!!!
Date published: 2020-05-11
Rated 5 out of 5 by from So Important Now! I always take this! It's a great product. I sometimes share with a friend
Date published: 2020-04-18
Rated 1 out of 5 by from No goldenseal, no deal The main reason why I have been buying this product is because it was with the goldenseal as previous customers have expressed. I too want to know what happened with the goldenseal? And why does it have the same product number and it's not the same product? Puritan what's up with that?
Date published: 2019-12-28
Rated 1 out of 5 by from No goldenseal, no deal The main reason why I have been buying this product is because it was with the goldenseal as previous customers have expressed. I too want to know what happened with the goldenseal? And why does it have the same product number and it's not the same product? Puritan what's up with that?
Date published: 2019-12-28
Rated 1 out of 5 by from Where's the Golden Seal? I bought this product originally because it was combined with Golden Seal. Then you removed the Golden Seal. WHY???
Date published: 2019-07-09
Rated 1 out of 5 by from No GoldenSeal Almost put this in my shopping cart. It has NO GOLDENSEAL as in the past. Same reorder number. Very misleading Puritan and is NOT the same product. I DO NOT recommend this as it is not a substitute for Goldenseal. Very unhappy and will need to buy Goldenseal elsewhere.
Date published: 2018-11-24
Rated 1 out of 5 by from No Goldenseal Root Not understanding why they changed this good product that worked well.
Date published: 2018-11-17
Rated 1 out of 5 by from I'm Confused Where is the Golden Seal.....? Same number for reorder, but the G>S> has been taken out... Why this is why I bought it. I take the plan Echinacea and it bust my immune system, but when I need and extra boost, I take the Ech. w/ G.S. and then I feel great. But the G.S. is not there any more???????????????
Date published: 2018-11-16
Rated 3 out of 5 by from Preference I prefer Echinacea with Goldenseal Root.... I have been taking that for years!!
Date published: 2018-04-16
Rated 1 out of 5 by from Confused It looks like the goldenseal has been removed from this formula but the reorder number has not changed. If I had not been paying attention I would have assumed the Echinacea Complex" included goldenseal; particularly because when you type in "Echinacea goldenseal" this product appears.
Date published: 2018-03-13
Rated 5 out of 5 by from Echinacea with Goldenseal Root Excellent products, excellent quality & excellent service. This company delivered as promised & every product that I have ordered has arrived in very good shape. In addition, I received a very nice email thanking me for my order. Great company to do business with! From a 1 - 10 rating, I give them a 10!
Date published: 2017-02-17
Rated 5 out of 5 by from Great product I have used this product for many years and value its effectiveness.
Date published: 2016-12-04
Date published: 2016-06-29
Rated 5 out of 5 by from Great product Echinacea with Goldenseal Root - Keeps my immune system in order. Love Puritan products. Have been a long time customer and will remain one. I also recommend Butchers broom 470 mg I believe that it helps me maintain the circulation in my legs. I am happy with this product.
Date published: 2016-03-16
Rated 5 out of 5 by from superb immune system health I have been using Puritan's Pride Echinacea with Goldenseal Root for many years for superb immune system health. I take this product daily and enjoy excellent health. I would be extremely disappointed if I were no longer able to benefit from this product. Thanks Puritan's Pride.
Date published: 2015-04-27
Rated 5 out of 5 by from Great Product! Puritan's Pride has excellent quality products, great service, prices and even the bottles are pretty! I will continue buying this product.
Date published: 2015-02-14
Rated 5 out of 5 by from Simply Perfect! I would definitely recommend purchasing the Goldenseal/Echinacea mix because my children have no issue with consuming small amounts of the powder. My oldest son can safely swallow a capsule and know that he is keeping his immune system strong. I have tried other products and this is the best one yet!
Date published: 2014-12-30
Rated 5 out of 5 by from best for maintain good health For many years I take Echinacea - my immune system is excellent.
Date published: 2014-10-16
Rated 5 out of 5 by from Excellent product Very happy to buy at Puritans Pride, and this product very good, outstanding presentation, and 100% recommended
Date published: 2014-10-11
Rated 5 out of 5 by from Works for me! I guess the proof is in the pudding and if the lab results on routine lab work show things are normal...then the products must be doing what they're supposed to be doing! Easy ordering...reasonable pricing... prompt shipping. Works for me!
Date published: 2014-07-29
Date published: 2014-07-05
Rated 5 out of 5 by from Echinacea Goldenseal fine product... great price point.. and prompt delivery. I'm very satisfied with this transaction.
Date published: 2014-06-25
Rated 5 out of 5 by from Wonderful product I believe that this product is helping stay healthy during this long, cold winter in the Northeast.
Date published: 2014-03-25
Rated 1 out of 5 by from Didn't work! Unlike my first order of this stuff, the last order I placed was a bad batch or something, and it didn't work at all. I even tried taking more capsules but with the same results.
Date published: 2013-07-30
Rated 5 out of 5 by from Immune system protector Since taking these last year, I was healthier than previous years, so when I ran out of them, bought more to keep taking.
Date published: 2013-01-10
Rated 5 out of 5 by from It is the combination that is important to me. The combination of these two herbs reacts well with my body. I use this product to help boost my immune system when needed. I have been using Echinecea and Goldenseal for at least 10 years and am very pleased, and the value can't be beat.
Date published: 2012-12-26
Rated 5 out of 5 by from Echinacea Goldenseal Echinacea Goldenseal was recommended by my friend as energy support. Good quality, good price.
Date published: 2012-12-04
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