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SAM-e 400 mg
SAM-e 400 mg
SAM-e 400 mg
SAM-e 400 mg
SAM-e 400 mg

SAM-e 400 mg

Item #013185

Earn up to 480 Puritan's Perks points. Learn More

  • Supports mood and emotional well-being**
  • Promotes healthy joint mobility and comfort**
  • Supports liver health**
  • Contains a 10 day to one month supply of caplets
  • Product is expiring August 2020.
Product & Label Information

SAM-e is a vital substance that's found in most of your cells and is essential to many biochemical reactions in the body.

Because of that, it serves many roles—including promoting joint comfort and liver health—but it's worth noting that SAM-e can support emotional well-being as well.**

Discovered by Italian scientist Giulio Cantoni in 1952, SAM-e has been used extensively in Europe for more than 20 years. SAM-e may play a role in increasing the synthesis and breakdown of certain neurotransmitters and enhance the sensitivity of nerve receptors in the brain.** To put it simply, SAM-e could help in supporting your mood.**

Because of age or other factors, levels of SAM-e can fluctuate or decline. And since SAM-e is not readily available in an everyday diet, a supplement may be just what you need to keep you moving with ease and feeling sunny and healthy.

About Puritan’s Pride

For more than 45 years, Puritan's Pride has helped families achieve a lifestyle of wellness. Our vitamins and supplements are made with care from the highest quality ingredients. They are tested or inspected as many as 15 times throughout the manufacturing process. That's why you can shop with confidence. We take pride in our products and helping customers feel their best.

Supplement Facts

Serving Size 1 Caplet
Amount Per Serving% Daily Value
  S-adenosylmethionine (SAM-e) 400 mg **
**Daily Value not established.
Directions: For adults, take one (1) caplet three times daily, preferably on an empty stomach. In order to obtain maximum benefits, SAM-e should be taken at least 30 minutes prior to a meal.

Other Ingredients: Vegetable Cellulose, Methacrylic Acid Copolymer. Contains <2% of: Magnesium Silicate, Mannitol, Silica, Sodium Starch Glycolate, Titanium Dioxide Color, Triethyl Citrate, Vegetable Magnesium Stearate, Vegetable Stearic Acid.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Store at room temperature. Do not use if blister seal is cut, torn or open.

No Artificial Flavor, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish, Sodium Free.

Customer Reviews
Rated 5 out of 5 by from Great product Been using for 5 years and very satisfied highly recommend it
Date published: 2020-03-26
Rated 5 out of 5 by from Wonderful product! I’ve been using Sam-E for years. It’s part of my morning routine.
Date published: 2020-03-25
Rated 5 out of 5 by from Every bit as good as any other brand of SAM-e! And you can't beat the price! I noticed a difference when I ran out and plan to never be without this supplement again!
Date published: 2020-03-02
Rated 5 out of 5 by from great product great efficacy level in product by puritan's pride. I have been a loyal customer for years!
Date published: 2020-02-27
Rated 5 out of 5 by from good value disposition is better, joints feel better. like feeling better
Date published: 2020-02-06
Rated 5 out of 5 by from I have been using Sam-E for 5 yrs and I saw improvement within a week and I'm very happy with the outcome. I just wish it wasn't so expensive. Great product. (;
Date published: 2019-08-05
Rated 5 out of 5 by from Immediate difference Started 400 mg SAM-e in early July 2015 after reading about it extensively. Experienced extremely positive results within minutes of taking first tablet. I just wish I'd known about it sooner. Every month, I order my SAM-e from Puritan's Pride. So thankful for such a high-quality product at a price that's affordable.
Date published: 2019-07-22
Rated 5 out of 5 by from Sam e is excellent I've been taking Sam e supplements for 10 years plus. Feel it helps with emotions and joints.
Date published: 2017-09-07
Rated 5 out of 5 by from Excellent product, works well for me Works very well with the St Johns Wort. I am very pleased with both products. Sincerely, DEK
Date published: 2016-12-14
Rated 5 out of 5 by from It Works SAM-e has done wonders for me and I feel so much better! I have been taking this product for about 3 months and will never go back. I take one caplet in the morning and was taking half of one in the late afternoon. However, I don't need it so only take one in the morning! If you are looking for a way out of "alternatives" and no negative side affects try SAM-e!
Date published: 2016-11-12
Rated 5 out of 5 by from SAMe 200 mg Great product and great price -- hard to fine this strength (200 mg) in the stores. Thanks to Puritan, I can easily order it.
Date published: 2016-11-10
Rated 5 out of 5 by from Excellent product. SAMe arrived quickly. Great product and great price from Puritan's Pride.
Date published: 2016-06-19
Rated 4 out of 5 by from Decent product This packaging and product is essentially identical to what I get from my market place where they sell "store-brand" generic vitamins at a lower price. Since that is the case, I will return to buying this satisfactory product from them.
Date published: 2016-02-09
Rated 5 out of 5 by from Actually worked Quickly Excellent product at reasonable price..
Date published: 2015-12-17
Rated 5 out of 5 by from Excellent product Used this Sam e for years. It works great and is the best value I have been able to find.
Date published: 2015-11-06
Rated 5 out of 5 by from Best Sam-E for the money I have been using this product for a few months and this is the best value out there. This one is a winner!
Date published: 2015-10-21
Rated 1 out of 5 by from Not Impressed With SAM-e. No noticeable improvement after using this rather expensive supplement!
Date published: 2015-10-09
Rated 4 out of 5 by from Good price The sale price was very good and the product arrived in a timely manner.
Date published: 2015-08-30
Rated 5 out of 5 by from Great picker upper I have used this product for several years. I'm in my 70's and my joints are doing great.
Date published: 2015-08-15
Rated 5 out of 5 by from Excellent product Have been taking for 6 months. Have noticed a difference in my mood.
Date published: 2015-04-28
Rated 3 out of 5 by from stop using thin fragile capsules for products -- can't open without destroying This does not apply to SAM-e It's other products.
Date published: 2015-02-26
Rated 5 out of 5 by from Super prices! I have noticed a big difference when I started taking these and that was at least 3 years ago.
Date published: 2015-02-21
Rated 5 out of 5 by from excellent product I've bought and used this purchase for years and I love it.
Date published: 2015-02-20
Rated 5 out of 5 by from better quality products I bought SAM-E 400mg from other web (other brand), this one is far better than other brand product. You can really feel the deference in quality, you feel more alert and focused your mind is so clear all day and you can be super productive all day long. I recommend not to over eat food during day time and take nutribullet super food smoothie at least once a day. you are going to feel amazing !!!!
Date published: 2014-11-20
Rated 4 out of 5 by from Product is good This product seems to be helping my condition, and will remain using it and continue to place orders as needed.
Date published: 2014-10-09
Rated 5 out of 5 by from Long Time User SAM-e was first prescribed for me over twelve years ago. I have continued to use SAM-e as I feel better when I take it. Puritan's price is the lowest I have found with absolutely no compromise in quality. I am truly grateful for this product.
Date published: 2014-09-21
Rated 5 out of 5 by from Great discovery, for me! I know I feel better with Sam-e in my life. New to this product, so will see what dosage is best for me, but initially, I am energized with 200 mg.
Date published: 2014-09-06
Rated 2 out of 5 by from Haven't seen a difference as of yet I haven't seen a difference with this product yet, I'll give it another week and if no difference I will not reorder.
Date published: 2014-09-04
Rated 4 out of 5 by from Very good product A friend suggested I try Sam-E. I've been taking Sam-E since I received my order from PP (a couple of weeks), and I am pleased with this product. A plus is that I know and trust PP products and will continue to purchase from PP as long as Sam-E works for me.
Date published: 2014-08-12
Rated 5 out of 5 by from Sam E This is a really great product and the value can't be beat. I have found it to be of great help in many areas of my physical being. This really helps in all areas.
Date published: 2014-07-06
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