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Vitamin D3 10 mcg (400 IU)
Vitamin D3 10 mcg (400 IU)
Vitamin D3 10 mcg (400 IU)
Vitamin D3 10 mcg (400 IU)
Vitamin D3 10 mcg (400 IU)

Vitamin D3 10 mcg (400 IU)

Item #001143
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immune icon

Not sure where to start
with immune health?

Then this is a great place to begin.
This content is intended as general information. We encourage you to explore the full Puritan’s Pride’s® Immune Health offerings for product-specific benefits.

Vitamin D for Immune Health

Vitamin D is a fat-soluble vitamin that can be obtained through the diet or synthesized in the skin upon exposure to sunlight. Vitamin D3, the form of vitamin D formed in the skin, is a potent and active form of the vitamin. Vitamin D2 is a vitamin D analog formed in plants, mushrooms and yeasts during photosynthesis. While vitamin D2 is sometimes used in food fortification, Puritan’s Pride supplements provide the active form.

Vitamin D plays a regulatory role in the growth, differentiation, and proliferation of different types of white blood cells.8** It is important to regulate these processes to maintain immune balance. Think of a thermostat set to 70 degrees.

When the temperature falls below 70 degrees the heat comes on but once the temperature is reached, the heat needs to turn off or else the temperature will continue to rise indefinitely. The same delicate balance is needed for our immune systems to maintain optimal health.

The T and B cells of the adaptive immune system are both regulated by vitamin D.** Many cells of the innate immune response also require vitamin D such as monocytes which need it to mature properly.** Adequate concentrations of vitamin D are also necessary for the synthesis of important proteins with immune-fighting properties.8**

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Why Supplement with Vitamin D?

As many as 96% of Americas do not get enough vitamin D from food alone.9

Did you know, Vitamin D is considered a nutrient of public health concern? This is because many Americas are not getting enough vitamin D in their diets and low intakes are associated with health concerns.

This is partly because natural food sources of vitamin D are limited and not always appealing. They include cod liver oil, liver and some types of fatty fish such as mackerel, salmon, and sardines. In the US, milk but not all dairy products, is fortified with vitamin D. It is important to check the label on products like cheese and yogurt to see if they were made with fortified milk.

The RDA for vitamin D is currently 15-20 mcg/day depending on age.

However, this level was established based on the amount of vitamin D needed to maintain bone health.** Many health experts argue that higher intakes of vitamin D are necessary for overall optimal health. A daily intake of 50 mcg (2,000 IU) is frequently recommended for most healthy adults.12


Unlike most vitamins that can only be obtained from the diet, our bodies produce vitamin D when the skin is exposed to sunlight. When evaluating if sun exposure is enough to meet your daily vitamin D needs, consider the following factors.

AGE

As we age, the skin produces vitamin D less efficiently. Vitamin D absorption may also decrease with age, making vitamin D supplementation especially beneficial for older individuals.

SUNSCREEN

When used as directed, a sunscreen graded SPF-10 will block 90% of UVB radiation reaching the skin.10 UVB radiation is needed to stimulate production of vitamin D.

LOCATION

Residents of northern climates may have inadequate exposure to sunlight in order to produce sufficient vitamin D, especially during the winter months.

CLOTHING

Wearing protective clothing such as hats and long sleeves inhibits the body’s natural production
of vitamin D.

SUN INTENSITY

The stimulation of vitamin D production in skin can depend on the intensity of the sun’s UVB rays. When you are shorter than your shadow, UVB radiation is often not strong enough to produce vitamin D.11 Air pollution and the presence of clouds can also have a major impact on the intensity of UVB radiation that reaches the ground.

  • References
  • 8. Gropper SS, Smith JL, Groff, JL. Fifth edition. Belmont, CA: Wadsworth/Cengage Learning; 2009.
  • 9. Dickinson A, MacKay D. Nutr J. 2014;13:14.
  • 10. Council on Environmental Health, Section on Dermatology, Balk SJ. Pediatrics. 2011 Mar;127(3):588-97.
  • 11. Gorham E. Vitamin D wiki website. October 2015. Accessed July 2, 2020. https://vitamindwiki.com/The+Shadow+Rule+%E2%80%93+you+make+Vitamin+D+when+you+are+taller+than+your+shadow+%E2%80%93+1992
  • 12. Calder PC, et al. Nutrients. 2020;12(4):1181.

What is the Immune System?

Every day, your body is bombarded by foreign substances from the outside world. Credit card pin pads, bathroom faucets, cell phones, literally everything you touch is covered in tiny microorganisms. Not all microorganisms are bad, in fact there are trillions of bacteria found in and on the human body which cause no harm, or in some cases are even beneficial to human health.

However, there are also less favorable microorganisms found in the environment. The main function of your immune system is to protect you from external threats and keep you healthy.

Think of your immune system as your body’s security team, trained to recognize and remove any threats while protecting your body’s peaceful residents.

The first line of defense is to restrict the entry of unwanted foreign materials. The skin creates an excellent physical barrier but unwanted guests may still be inhaled or ingested. The acidity of stomach acid, mucosal membranes, and the presence of antibodies in saliva and tears all further help to prevent the entry of these substances into the body.

Four Main Functions
of the Immune System

icon exclusion
Exclusion Barrier

Physical barriers keep pathogens from entering the body – e.g. skin, mucosa layer of GI tract, antibodies in saliva, pH of stomach

icon recognition
Recognition

If substances get through the exclusion barrier, they need to be recognized as non-self

icon elimination
Elimination

Elimination only of unwanted threats, not self or friendly bacteria

icon memory
Memory

Immune memories allow for fast recognition and elimination of repeat offenders


1

Your First Line of Defense: Innate Immune System

If a non-beneficial microorganism is able to pass through your body’s first line of defense, it must be recognized by your immune system. Recognition is an important feature of your patrolling security team. Without it, your immune system would attack non-threatening foreign substances and even your own cells. Undesirable substances are recognized by white blood cells that send messages akin to sounding an alarm, drawing more white blood cells to the area. There are many different types of white blood cells, also called leukocytes, that all work together to orchestrate the appropriate immune response. The elements of the immune system discussed thus far are all considered part of the innate response.

Characterized as being fast and non-specific, the innate immune system responds within minutes or hours.1 Once the innate immune system has identified a threat, it seeks to eliminate it. The various white blood cells of the innate immune system each fight these threats in their own unique ways. Some will trigger an inflammatory response while others will deal with it directly by engulfing it or releasing toxic chemicals. Since the innate immune response is non-specific, the response is generally the same regardless of whether the same pathogen is encountered numerous times.


2

Your Second Line of Defense: Adaptive Immune Response

If a non-beneficial microorganism is able to pass through your body’s first line of defense, it must be recognized by your immune system. Recognition is an important feature of your patrolling security team. Without it, your immune system would attack non-threatening foreign substances and even your own cells. Undesirable substances are recognized by white blood cells that send messages akin to sounding an alarm, drawing more white blood cells to the area. There are many different types of white blood cells, also called leukocytes, that all work together to orchestrate the appropriate immune response. The elements of the immune system discussed thus far are all considered part of the innate response.

Characterized as being fast and non-specific, the innate immune system responds within minutes or hours.1 Once the innate immune system has identified a threat, it seeks to eliminate it. The various white blood cells of the innate immune system each fight these threats in their own unique ways. Some will trigger an inflammatory response while others will deal with it directly by engulfing it or releasing toxic chemicals. Since the innate immune response is non-specific, the response is generally the same regardless of whether the same pathogen is encountered numerous times.

Factors that
Affect Immune Health

Your immune system is always patrolling your body to keep you at your best, but you need to keep your immune system healthy too. Every day you need to provide your immune system with the energy and nutrients it needs to function optimally.

age block

AGE: The immune response starts to weaken around age 60 and continues to weaken with age.2

sleep block

SLEEP: Important immune proteins called cytokines are released while we sleep. Sleep deprivation leads to decreased immune function as well as increased recovery times.3

stress block

STRESS: Both physical and emotional stress can negatively impact the immune system. The stress hormone cortisol has been shown to decrease white blood cell numbers.7

smoking block

SMOKING:: Smoking causes dysfunction of white blood cells involved in both innate and adaptive immunity.5 It is estimated that 1.1 billion people in the world are smokers.6

sleep block

PHYSCIAL ACTIVITY: Regular moderate-intensity exercise achieved on a near-daily basis is associated with better immune health with age. More than 80% of U.S. adults are not meeting guidelines for both aerobic and muscle-strengthening activities.4

stress block

NUTRITION: The immune system needs proper nutrients to function optimally. There are a number of vitamins, minerals and other nutrients that are widely recognized for their role in supporting immune health.**

Immune
Myths & FAQs
Myth: All immune support supplements work the same way.

Because the immune system is such a complex system, there is not a one-size-fits-all approach to supporting immune health. The various different types of white blood cells, immune proteins, and tissues and organs all have different nutrient requirements. Taking a single nutrient for immune health may assist in supporting one of these aspects of immune health, but if you are lacking other nutrients in your diet, then you may be falling short in getting total immune support.**

Myth: The immune system is stronger in the summer.

The immune system works year-round to keep you healthy no matter what the season. Depending on location and lifestyle factors, vitamin D status may be higher in the summer to better support certain aspects of immune health.** Winter weather conditions such as dry air may also affect immune health. It is still important to support your immune health every day throughout the year for optimal functioning.

FAQ: How can you boost your immune system?

The immune system should not be “boosted” beyond normal, optimal functioning. In fact, many autoimmune diseases are characterized by an overactive immune system that starts attacking its own cells. There are however lifestyle changes that you can make to help support normal functioning of the immune system. These include getting adequate sleep, engaging in regular physical activity, managing stress, eating a balanced diet and getting adequate amounts of immune supporting nutrients.

FAQ: Where is the immune system?

The immune system is a complex network of organs, cells, tissues and proteins found throughout the body. It includes the thymus, spleen, bone marrow, skin, tonsils and Peyer’s patches in the intestines. The lymph system allows white blood cells of the immune system to patrol the entire body looking for foreign invaders.

References:

  • 1. Gombart AF, Pierre A, Maggini S. Nutrients. 2020;12(1):236.
  • 2. Pawelec G, Larbi A, Derhovanessian E. J Comp Pathol. 2010;142 Suppl 1:S39-S44.
  • 3. Krueger JM, Majde JA, Rector DM. Cytokines in Immune Function and Sleep Regulation.; 2011. doi:10.1016/B978-0-444-52006-7.00015-0
  • 4. President’s Council on Sports, Fitness & Nutrition. U.S. Department of Health and Human Services Website. Updated January 26, 2017. Accessed July 2, 2020. https://www.hhs.gov/fitness/resource-center/facts-and-statistics/index.html
  • 5. Qiu F, Liang CL, Liu H, et al. Oncotarget. 2017;8(1):268-284.
  • 6. Tobacco. https://www.who.int/news-room/fact-sheets/detail/tobacco. Accessed March 24, 2020.
  • 7. McGregor BA, Murphy KM, Albano DL, Ceballos RM. Stress. 2016;19(2):185-191.

Why Choose Puritan’s Pride?

Getting the most out of life every day is what inspires us to deliver over 3,000 outstanding products that help you achieve your health and wellness goals.

We take pride in manufacturing the vitamins, minerals and herbal supplements that complement your healthy lifestyle, plus we offer essential oils, nutritious foods and more.

So get out there and embrace life… because the journey is your reward.

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Customer Reviews
Rated 5 out of 5 by from GREAT VALUE AND HIGH D3 FANTASTIC PRICING, FAST SHIPPING, WILL DEFINUTLY BUY AGAIN.
Date published: 2020-05-18
Rated 5 out of 5 by from Great value! I bought this a few months ago and the price was incredible!
Date published: 2020-04-22
Rated 5 out of 5 by from Well made I’ve been buying this for my 92 year old mother who doesn’t get out in the sun or drink enough milk. Her doctor is pleased with her health.
Date published: 2020-04-18
Rated 1 out of 5 by from the product itself is fine... it's the endless incessant popup ads I can't stand
Date published: 2020-03-27
Rated 5 out of 5 by from Good product Like this product, is the dosage my husband and I needed and our doctor approved. Good price too.
Date published: 2019-12-23
Rated 5 out of 5 by from Excellent Ordered the product and was here on time. Better than going to the store.
Date published: 2016-12-29
Rated 5 out of 5 by from Excellent products This is the only place i come to to buy what i need because the products are excellent and trustworthy and customer service is awesome
Date published: 2016-10-31
Rated 5 out of 5 by from What I Was Looking For Puritans Pride is my 1st choice of company to buy supplements from, but I am especially happy with this 400 IU Vitamin D because it is the dosage I need. Thank you, Puritans Pride for all your many great products!
Date published: 2016-07-30
Rated 4 out of 5 by from Good product Product quantity and quality are very sufficient in supplementing my bone health.
Date published: 2016-07-14
Rated 5 out of 5 by from great price and timely delivery These are just what I needed. The price was right and free delivery!
Date published: 2016-05-03
Rated 1 out of 5 by from Gel capsule preferred I would probably purchase this again if it was available as a gel capsule. Tablets are difficult to swallow for me.
Date published: 2016-01-09
Rated 5 out of 5 by from Excellent Product I use this to supplement my Vitamin D levels along with my calcium pills. My husband now has to take this so I will be ordering a higher dose pill on my next order. This pill is an excellent value as are all the other Puritan Pride products.
Date published: 2015-12-27
Rated 5 out of 5 by from Works great for me. This gel cap is smaller than the capsuls I have been using. It is easy to swallow and good for me.
Date published: 2015-08-30
Rated 5 out of 5 by from Excellent The ingredients in this Vitamin D3 are great. PP quality, value, and shipping are excellent!
Date published: 2015-08-29
Rated 5 out of 5 by from Excellent Price Its nice to find a Vitamin D product that does not contain soybean oil.
Date published: 2015-08-27
Rated 5 out of 5 by from great overall I feel that the vitamin d product we ordered is an excellent value for the money. The price is also a great value as well. I love puritans pride and buy all of my supplemental needs here.
Date published: 2015-07-14
Rated 5 out of 5 by from Excellent Product and Prices! Highly recommend your products and company! We cannot beat your prices. Excellent quality, delivery and no hassle. Thank you for caring and your superior service.
Date published: 2015-04-12
Rated 5 out of 5 by from excellent value for the price. Since I don't get out into the sun much as I have grown older I am confident that these vitamins meet my requirement for Vitamin D so my bones stay healthy and strong in my later years.
Date published: 2015-03-25
Rated 5 out of 5 by from Vitamin D3 400 IU came in a timely manner, just what i ordered, doesn't go way beyond what is recommended for V3 intake.
Date published: 2015-01-21
Rated 5 out of 5 by from Excellent product I have used this product for 4-5 years. It has kept my Vitamin D where the doctor wants it.
Date published: 2015-01-15
Rated 5 out of 5 by from Vit D 400 mg Tablets These are okay and a good deal but they are tablets not gels which I wanted you need to read what your buying. Evedently I didn't but they work just as well.
Date published: 2014-12-28
Rated 4 out of 5 by from Great discounts. I have been buying my supplements from you for a long time now, and have never experienced a more affordable way to stock up on the products I use.
Date published: 2014-11-10
Rated 5 out of 5 by from Great Sale Pricing with free shipping too I have been using their Vitamin D3 for a few years now. I just purchased a years supply the month prior to their last sale. The sale price was so good, I just had to buy another bottle. Along with free shipping, I couldn't pass this sale up. Puritan's Pride's regular pricing is always very competitive with other internet sellers. However, their sale prices are outstanding. I have never had a problem over the years with their products or service, so Why shop anywhere else?
Date published: 2014-11-07
Rated 5 out of 5 by from Very nice I like very much the shape of it - it is rare and feels very pleasant. As for coating, it feels powdery, I jist wish it were more like M&Ms'. They say that they use special Sunvite technology, but I didn't find on their site what it is.
Date published: 2014-11-06
Rated 5 out of 5 by from Fast service, great prices Summary above says it all. Can't think why anyone would shop elsewhere.
Date published: 2014-10-12
Rated 5 out of 5 by from Excellent! While there is something to be said for the larger doses, and being able to take only one pill, I prefer the 400IU as I can adjust my dosages as I get more or less sun daily. Great value for the money, fast shipping from a name I can trust. Thank you, Puritan's Pride.
Date published: 2014-09-06
Rated 1 out of 5 by from Difficult to swallow I have swallowed thousands of pills sometimes even with little or no water, but I don't remember ever encountering a pill as difficult to swallow as this one. It is poorly engineered and somehow just gets stuck in my throat. I don't look forward to having to struggle with one of these pills every day for the next year and a half. That said, I am generally satisfied with Puritan Pride's prices and service. Orders always arrive promptly.
Date published: 2014-08-10
Rated 5 out of 5 by from Vitamin D is necessity for me. Very good product, very good value. Small, easy to swallow
Date published: 2014-03-20
Rated 4 out of 5 by from Easy to take Vit D The product is fine, the packaging is not fine. The styrofoam peanuts fly all over the place in low humidity and should be discontinued. There are better alternatives to use. It annoys me so much that I may have to buy elsewhere.
Date published: 2014-03-14
Rated 5 out of 5 by from good product found the strength of tablet desired, large enough quantity and the lowest price
Date published: 2013-06-30
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