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Vitamin D3 125 mcg (5000 IU) Sale 85% Off
Vitamin D3 125 mcg (5000 IU) Sale 85% Off
Vitamin D3 125 mcg (5000 IU) Sale 85% Off
Vitamin D3 125 mcg (5000 IU) Sale 85% Off
Vitamin D3 125 mcg (5000 IU) Sale 85% Off

Vitamin D3 125 mcg (5000 IU)

Item #019377

Additional discounts will not apply to this item.

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Sale 85% Off

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IMPORTANT NOTICE:
Limit of 25 per sale item
  • Supports healthy bones and teeth**
  • An essential nutrient that aids in Calcium absorption**
  • Helps maintain a healthy immune system**
  • Vitamin D3 is a more potent and bioavailable form compared to D2
  • Contains a three-month supply of easy-to-swallow softgels

VIEW SUPPLEMENT FACTS Read Reviews
immune icon

Not sure where to start
with immune health?

Then this is a great place to begin.
This content is intended as general information. We encourage you to explore the full Puritan’s Pride’s® Immune Health offerings for product-specific benefits.

Vitamin D for Immune Health

Vitamin D is a fat-soluble vitamin that can be obtained through the diet or synthesized in the skin upon exposure to sunlight. Vitamin D3, the form of vitamin D formed in the skin, is a potent and active form of the vitamin. Vitamin D2 is a vitamin D analog formed in plants, mushrooms and yeasts during photosynthesis. While vitamin D2 is sometimes used in food fortification, Puritan’s Pride supplements provide the active form.

Vitamin D plays a regulatory role in the growth, differentiation, and proliferation of different types of white blood cells.8** It is important to regulate these processes to maintain immune balance. Think of a thermostat set to 70 degrees.

When the temperature falls below 70 degrees the heat comes on but once the temperature is reached, the heat needs to turn off or else the temperature will continue to rise indefinitely. The same delicate balance is needed for our immune systems to maintain optimal health.

The T and B cells of the adaptive immune system are both regulated by vitamin D.** Many cells of the innate immune response also require vitamin D such as monocytes which need it to mature properly.** Adequate concentrations of vitamin D are also necessary for the synthesis of important proteins with immune-fighting properties.8**

icon lightbulb
Why Supplement with Vitamin D?

As many as 96% of Americans do not get enough vitamin D from food alone.9

Did you know, Vitamin D is considered a nutrient of public health concern? This is because many Americas are not getting enough vitamin D in their diets and low intakes are associated with health concerns.

This is partly because natural food sources of vitamin D are limited and not always appealing. They include cod liver oil, liver and some types of fatty fish such as mackerel, salmon, and sardines. In the US, milk but not all dairy products, is fortified with vitamin D. It is important to check the label on products like cheese and yogurt to see if they were made with fortified milk.

The RDA for vitamin D is currently 15-20 mcg/day depending on age.

However, this level was established based on the amount of vitamin D needed to maintain bone health.** Many health experts argue that higher intakes of vitamin D are necessary for overall optimal health. A daily intake of 50 mcg (2,000 IU) is frequently recommended for most healthy adults.12


Unlike most vitamins that can only be obtained from the diet, our bodies produce vitamin D when the skin is exposed to sunlight. When evaluating if sun exposure is enough to meet your daily vitamin D needs, consider the following factors.

AGE

As we age, the skin produces vitamin D less efficiently. Vitamin D absorption may also decrease with age, making vitamin D supplementation especially beneficial for older individuals.

SUNSCREEN

When used as directed, a sunscreen graded SPF-10 will block 90% of UVB radiation reaching the skin.10 UVB radiation is needed to stimulate production of vitamin D.

LOCATION

Residents of northern climates may have inadequate exposure to sunlight in order to produce sufficient vitamin D, especially during the winter months.

CLOTHING

Wearing protective clothing such as hats and long sleeves inhibits the body’s natural production
of vitamin D.

SUN INTENSITY

The stimulation of vitamin D production in skin can depend on the intensity of the sun’s UVB rays. When you are shorter than your shadow, UVB radiation is often not strong enough to produce vitamin D.11 Air pollution and the presence of clouds can also have a major impact on the intensity of UVB radiation that reaches the ground.

  • References
  • 8. Gropper SS, Smith JL, Groff, JL. Fifth edition. Belmont, CA: Wadsworth/Cengage Learning; 2009.
  • 9. Dickinson A, MacKay D. Nutr J. 2014;13:14.
  • 10. Council on Environmental Health, Section on Dermatology, Balk SJ. Pediatrics. 2011 Mar;127(3):588-97.
  • 11. Gorham E. Vitamin D wiki website. October 2015. Accessed July 2, 2020. https://vitamindwiki.com/The+Shadow+Rule+%E2%80%93+you+make+Vitamin+D+when+you+are+taller+than+your+shadow+%E2%80%93+1992
  • 12. Calder PC, et al. Nutrients. 2020;12(4):1181.

What is the Immune System?

Every day, your body is bombarded by foreign substances from the outside world. Credit card pin pads, bathroom faucets, cell phones, literally everything you touch is covered in tiny microorganisms. Not all microorganisms are bad, in fact there are trillions of bacteria found in and on the human body which cause no harm, or in some cases are even beneficial to human health.

However, there are also less favorable microorganisms found in the environment. The main function of your immune system is to protect you from external threats and keep you healthy.

Think of your immune system as your body’s security team, trained to recognize and remove any threats while protecting your body’s peaceful residents.

The first line of defense is to restrict the entry of unwanted foreign materials. The skin creates an excellent physical barrier but unwanted guests may still be inhaled or ingested. The acidity of stomach acid, mucosal membranes, and the presence of antibodies in saliva and tears all further help to prevent the entry of these substances into the body.

Four Main Functions
of the Immune System

icon exclusion
Exclusion Barrier

Physical barriers keep pathogens from entering the body – e.g. skin, mucosa layer of GI tract, antibodies in saliva, pH of stomach

icon recognition
Recognition

If substances get through the exclusion barrier, they need to be recognized as non-self

icon elimination
Elimination

Elimination only of unwanted threats, not self or friendly bacteria

icon memory
Memory

Immune memories allow for fast recognition and elimination of repeat offenders


1

Your First Line of Defense: Innate Immune System

If a non-beneficial microorganism is able to pass through your body’s first line of defense, it must be recognized by your immune system. Recognition is an important feature of your patrolling security team. Without it, your immune system would attack non-threatening foreign substances and even your own cells. Undesirable substances are recognized by white blood cells that send messages akin to sounding an alarm, drawing more white blood cells to the area. There are many different types of white blood cells, also called leukocytes, that all work together to orchestrate the appropriate immune response. The elements of the immune system discussed thus far are all considered part of the innate response.

Characterized as being fast and non-specific, the innate immune system responds within minutes or hours.1 Once the innate immune system has identified a threat, it seeks to eliminate it. The various white blood cells of the innate immune system each fight these threats in their own unique ways. Some will trigger an inflammatory response while others will deal with it directly by engulfing it or releasing toxic chemicals. Since the innate immune response is non-specific, the response is generally the same regardless of whether the same pathogen is encountered numerous times.


2

Your Second Line of Defense: Adaptive Immune Response

The body’s second line of defense is the adaptive immune response. This response takes days or even weeks to develop, but it is highly specific. Unlike the innate immune system which simply recognizes objects as good or bad, the adaptive immune system precisely identifies each foreign substance and develops a customized response. These unwanted guests are identified by the presence of antigens – which are like name tags calling out what kind of substance it is. Highly specialized white blood cells called B cells produce antibodies that fit together with the foreign substances antigens like puzzle pieces. The antibody-antigen complex signals to other immune cells that this complex needs to be destroyed.

Another type of cell of the adaptive immune system is T cells. T cells do not produce antibodies but when they recognize an antigen, some types of T cells will directly attack the foreign invader. Other types of T cells will regulate the responses of other types of immune cells. The most amazing part about the adaptive immune system is its capacity to remember the appropriate response for foreign substance through memory cells. These immune memories develop throughout your life and are readily activated when they are needed again.

Factors that
Affect Immune Health

Your immune system is always patrolling your body to keep you at your best, but you need to keep your immune system healthy too. Every day you need to provide your immune system with the energy and nutrients it needs to function optimally.

age block

AGE: The immune response starts to weaken around age 60 and continues to weaken with age.2

sleep block

SLEEP: Important immune proteins called cytokines are released while we sleep. Sleep deprivation leads to decreased immune function as well as increased recovery times.3

stress block

STRESS: Both physical and emotional stress can negatively impact the immune system. The stress hormone cortisol has been shown to decrease white blood cell numbers.7

smoking block

SMOKING: Smoking causes dysfunction of white blood cells involved in both innate and adaptive immunity.5 It is estimated that 1.1 billion people in the world are smokers.6

sleep block

PHYSICAL ACTIVITY: Regular moderate-intensity exercise achieved on a near-daily basis is associated with better immune health with age. More than 80% of U.S. adults are not meeting guidelines for both aerobic and muscle-strengthening activities.4

stress block

NUTRITION: The immune system needs proper nutrients to function optimally. There are a number of vitamins, minerals and other nutrients that are widely recognized for their role in supporting immune health.**

Immune
Myths & FAQs
Myth: All immune support supplements work the same way.

Because the immune system is such a complex system, there is not a one-size-fits-all approach to supporting immune health. The various different types of white blood cells, immune proteins, and tissues and organs all have different nutrient requirements. Taking a single nutrient for immune health may assist in supporting one of these aspects of immune health, but if you are lacking other nutrients in your diet, then you may be falling short in getting total immune support.**

Myth: The immune system is stronger in the summer.

The immune system works year-round to keep you healthy no matter what the season. Depending on location and lifestyle factors, vitamin D status may be higher in the summer to better support certain aspects of immune health.** Winter weather conditions such as dry air may also affect immune health. It is still important to support your immune health every day throughout the year for optimal functioning.

FAQ: How can you boost your immune system?

The immune system should not be “boosted” beyond normal, optimal functioning. In fact, many autoimmune diseases are characterized by an overactive immune system that starts attacking its own cells. There are however lifestyle changes that you can make to help support normal functioning of the immune system. These include getting adequate sleep, engaging in regular physical activity, managing stress, eating a balanced diet and getting adequate amounts of immune supporting nutrients.

FAQ: Where is the immune system?

The immune system is a complex network of organs, cells, tissues and proteins found throughout the body. It includes the thymus, spleen, bone marrow, skin, tonsils and Peyer’s patches in the intestines. The lymph system allows white blood cells of the immune system to patrol the entire body looking for foreign invaders.

References:

  • 1. Gombart AF, Pierre A, Maggini S. Nutrients. 2020;12(1):236.
  • 2. Pawelec G, Larbi A, Derhovanessian E. J Comp Pathol. 2010;142 Suppl 1:S39-S44.
  • 3. Krueger JM, Majde JA, Rector DM. Cytokines in Immune Function and Sleep Regulation.; 2011. doi:10.1016/B978-0-444-52006-7.00015-0
  • 4. President’s Council on Sports, Fitness & Nutrition. U.S. Department of Health and Human Services Website. Updated January 26, 2017. Accessed July 2, 2020. https://www.hhs.gov/fitness/resource-center/facts-and-statistics/index.html
  • 5. Qiu F, Liang CL, Liu H, et al. Oncotarget. 2017;8(1):268-284.
  • 6. Tobacco. https://www.who.int/news-room/fact-sheets/detail/tobacco. Accessed March 24, 2020.
  • 7. McGregor BA, Murphy KM, Albano DL, Ceballos RM. Stress. 2016;19(2):185-191.

Why Choose Puritan’s Pride?

Getting the most out of life every day is what inspires us to deliver over 3,000 outstanding products that help you achieve your health and wellness goals.

We take pride in manufacturing the vitamins, minerals and herbal supplements that complement your healthy lifestyle, plus we offer essential oils, nutritious foods and more.

So get out there and embrace life… because the journey is your reward.

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Trusted and Loved
by Generations of Families
for Over 45 Years


  • Highest Quality Vitamins
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Customer Reviews
Rated 5 out of 5 by from Great product I am glad I use this product daily and feel very healthy. I am big supporter of daily vitamins
Date published: 2020-11-05
Rated 3 out of 5 by from I ordered 3 bottles of Probiotic acidophilus in August . each bottle has 250 capsults to be taken one a day . I received 3 more bottles free, but they all expire on 10/21. So what can I do with all these bottles 2 bottles are also too much to use up to 10/21. It was a waste of money .
Date published: 2020-10-31
Rated 5 out of 5 by from Vitamin D3 Having great results with it. My doctor told me I needed to take this and am glad of this product available through Puritans Pride.
Date published: 2020-10-26
Rated 5 out of 5 by from Vit d3 I find the product to be of good quality and a good value. I will continue to purchase from puritan pride 4 all my supplement needs.
Date published: 2020-10-25
Rated 1 out of 5 by from Bottle had wrong count Was labelled as 250 (as I recall) count but only had about 100 in it.
Date published: 2020-10-25
Rated 5 out of 5 by from great I don't get outdoors to much so with taking vitamin D3 125mcg it supplements for the sun
Date published: 2020-10-23
Rated 2 out of 5 by from It Fair Its a good vitamin but bit expensive for what you get and what it is there are better price deals around then here
Date published: 2020-10-23
Rated 5 out of 5 by from My new favorite product I bought this product so happy I did. Thanks Purtain Pride..
Date published: 2020-10-22
Rated 5 out of 5 by from Great product very good quality to buy.Highly recommended........
Date published: 2020-10-17
Rated 5 out of 5 by from A staple in my regimen This strength Vitamin D is a staple in my home. I prefer Puritan's Pride because of the strength and value. So important.
Date published: 2020-10-05
Rated 5 out of 5 by from This product is the best value and quality available.
Date published: 2020-10-04
Rated 5 out of 5 by from Right formula I bought this several years ago and it has the correct formula.
Date published: 2020-09-26
Rated 4 out of 5 by from Vitamin D3 Recommended by my doctor, easy to swallow gell tablet. When I get my next blood draw, I'll let you know how well it's working.
Date published: 2020-09-25
Rated 5 out of 5 by from Vitamin D3 125 mcg (5000 IU) Great Price! This Vitamin D3 125 mcg (5000 IU) really is better priced than the other Vit D out there. The fact that it's so small in packaging makes it very handy and convinent to carry and have around all the time, anywhere. It does the job and does it well. I will keep buying this and stock up. We don't want to run out of this, now do we? :)
Date published: 2020-09-19
Rated 5 out of 5 by from 2 in 1 ingredients I bought it for my fiance' and he really needed it.
Date published: 2020-09-18
Rated 5 out of 5 by from Great features Glad to find this size bottle on your website,and in your book
Date published: 2020-09-18
Rated 5 out of 5 by from Great product I bought this product and am so happy that I did...
Date published: 2020-09-04
Rated 5 out of 5 by from Great product! Best prices for the quality as well as quantity. I will definitely purchase again.
Date published: 2020-09-03
Rated 5 out of 5 by from easy to swallow brought my levels up and are helping me maintain proper Vit D
Date published: 2020-08-29
Rated 5 out of 5 by from Great size I have Ben taking this product for several years and I appreciate a lot of product in a small gel capsule. Easy to swallow.
Date published: 2020-08-24
Rated 1 out of 5 by from To soon to review this product Takes a while for Vitamin D to build up in your system. Cannot give a honest review in 3 weeks. As a matter of fact I don' see how I can review this product until I get bloodwork in future.
Date published: 2020-08-23
Rated 5 out of 5 by from Vitamin D I have been taking this for years. My orthopedic doctor, internist and Rheumatoid doctor all recommended that I take this daily.
Date published: 2020-08-20
Rated 4 out of 5 by from Easily tolerated Easily ordered, reasonably priced and shipped promptly.
Date published: 2020-08-14
Rated 5 out of 5 by from Superior quality I switched from drugstore version because Puritan’s products are excellent.
Date published: 2020-08-12
Rated 5 out of 5 by from Vitamin D3 So far my family and I are pleased with this product.
Date published: 2020-08-07
Rated 5 out of 5 by from Best value for an essential vitamin. D3 should be a basic supplement because of all it's benefits. 5000 IU is a good dosage. And, Puritans Pride has a good price for this product. Also, because of the quantity they sell, you know it's fresh, especially important for an oil based product.
Date published: 2020-08-06
Rated 5 out of 5 by from good pricing for this item. I assume it is helping me being I get NO sun being locked in.
Date published: 2020-07-26
Rated 5 out of 5 by from great 2 know you are protected when going outside from sun exposure, also you will feel energy with the powerful output of your immune system
Date published: 2020-07-25
Rated 5 out of 5 by from I have been buying D3 from Puritan Pride for many years. It helps me very often to feel good.
Date published: 2020-07-23
Rated 1 out of 5 by from use D3 every day! I have been using D3 for many years, take the 5000 IU in the fall and winter months. Always buy this only from Puritan Pride when it is on sale for buy 2 get 2 free!
Date published: 2020-07-18
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